evaluation of oogenesis aspects in neonatal and adult mice after toloaldoxime treatment

نویسندگان

mohammad fazeltabar malekshah

mahsa sedighi

kazem parivar

homa mohseni kouchesfahani

چکیده

objective: oximes are important materials in organic chemistry. synparamethyl benzaldehyde oxime (toloaldoxime) is structurally similar to other oximes, hence we have studied its effects on the neonatal and adult female balb/c mice reproductive systems in order to provide a platform for future studies on the production of female contraceptive drugs. materials and methods: in experimental study, we studied the effects of toloaldoxime on ovary growth and gonadal hormones of neonatal and adult balb/c mice. a regression model for prediction was presented. results: the effects of toloaldoxime on neonatal mice were more than adult mice. the greatest effect was on the number of graafian follicles (59.6% in adult mice and 31.83% in neonatal mice). the least effect was on ovary weight, and blood serum levels of follicle stimulating hormone (fsh) and luteinizing hormone (lh). conclusion: according to the data obtained, toloaldoxime can be considered an antipregnancy substance.

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Evaluation of Oogenesis Aspects in Neonatal and Adult Mice after Toloaldoxime Treatment

OBJECTIVE Oximes are important materials in organic chemistry. Synparamethyl benzal- dehyde oxime (toloaldoxime) is structurally similar to other oximes, hence we have studied its effects on the neonatal and adult female Balb/c mice reproductive systems in order to provide a platform for future studies on the production of female contraceptive drugs. MATERIALS AND METHODS In experimental stud...

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عنوان ژورنال:
cell journal

جلد ۱۷، شماره ۳، صفحات ۵۶۴-۵۶۸

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